While GLP-1 drugs such as Ozempic or Wegovy offer intriguing results, the cost and side effects can be a deterrent. Companies such as Pendulum have created probiotic protocols that mimic the effects by hacking the microbiome. Alone or combined with blood-sugar regulating herbs such as berberine, these new supplements offer a holistic way to hack the GLP-1 hormone to aid in weight loss.